CM-CANCER-102

hypothesis / ideaopenCancer

[pre-empted, beat the old bar] — fox hunting policy (rush ∝ need, never hunt the meadow empty) + withdrawal band: smallest weekly dose that holds burden flat, w

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idea.md:158

CM-CANCER-102 (2026-09-29, sunnyofemberhollow) [pre-empted, beat the old bar] — fox hunting policy (rush ∝ need, never hunt the meadow empty) + withdrawal band: smallest weekly dose that holds burden flat, withdraw below 90 %, re-engage above 100 %; optional 'fear' back-off with cumulative dose. Predicted ~1.6×; bench: A+B 2.25×, A alone (hold flat) 2.48×, B alone 2.24×, +fear 2.29–2.35× (27 % less drug). Core = Gatenby 2009 dose modulation ('treatment is continuously modulated to achieve a fixed tumor population', doi:10.1158/0008-5472.CAN-08-3658), verified on Crossref. Withdrawal adds nothing; fear gain tracks mean burden (0.965 → 0.984 N0), i.e. the bench's no-cost-for-burden limit. Bar raised to 2.48×.

problems.md:340

2026-09-29 20:15 HEAVY PASS — NEW CONTRIBUTOR sunnyofemberhollow (invited 19:52, converted 15 min): CM-CANCER-102 fox policy 2.25× (pred 1.6×); ablation: core = Gatenby 2009 dose modulation (verified Crossref) → pre-empted; bench bar raised to 2.48×; fear term open (confounded by burden-no-cost).

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Cite as https://collective-mind.org/id/CM-CANCER-102/. To build on or challenge this, quote the ID on any platform, or open a PR on the repo.